Products & Breakthough technology

Unlike the spherical shape of the classical microcarriers of the market, Carroucell create microcarriers with flat disc shape, bringing significant advantages in cell culture. The tight control of Carroucell micro disc size, with a variability of barely 20%, and composition brings a crucial adaptability for each cell types and amplification processes.

Carroucell microcarriers sol-gel synthesis process allows for full customization to best match cell culture needs. With this extreme flexibility, Carroucell aims to change the paradigm in the microcarrier field, and more generally, in all biotechnology fields involving the large-scale production of adherent cells.

Carroucell sol-gel synthesis process permits to propose an eco-friendly glass, and more importantly, eco-friendly microcarriers.

Unlike classic glass materials, manufactured at extreme high temperatures, Carroucell microcarriers are synthetized at room temperature. This results in a 90% reduction of the energy footprint associated with Carroucell microcarriers synthesis.

More than that, Carroucell sol-gel microcarriers synthesis process meet the requirements of green chemistry. Manufacturing microcarriers composed of glass and with 0 plastic components, Carroucell synthesis process do not require any solvent harmful for the environment.

In Carroucell sol-gel microcarrier synthesis process, 0 animal or plant-based components are used. This guaranties microcarriers with no batch-to-batch variation and by extension, to a high reproducibility in your cell amplification processes.

Sizes : 165 +/- 35µm et 275+/-75µm

Composition : 100% fonctionnalized green silica

Aggregation-related mortality, hindered cell harvesting, and complexities arising from high microcarrier concentrations pose significant bottlenecks in traditional cell culture on microcarriers, impacting scale-up and production cost reductions. With the purpose to bring bioproduction efficiency to its next level, we bring to the market a new generation of microcarrier: PowerScaleTM.

Carroucell PowerScaleTM microcarriers stand apart from their spherical counterparts on the market, offering a multitude of advantages. Firstly, they boast a remarkable 15-fold increase in specific surface area compared to conventional microcarriers. This means that just 1 gram of PowerScaleTM microcarriers provides over 5000 cm2 of adherence surface for cells.

The unique flat disc shape of PowerScaleTM microcarriers optimizes cell adherence, reduces cell mortality from aggregation, and enhances cell detachment. Their transparent design allows easy monitoring of cell adhesion and growth. Precise control over microcarrier size improves culture homogeneity and filtration. Made from pure and flexible silica, PowerScaleTM microcarriers offer exceptional inertness and durability, providing a stable scaffold for scale-up operations.

Finally, Carroucell sol-gel technology enables the customization of PowerScaleTM microcarriers. This adaptability ensures that the microcarriers can meet the specific requirements for any types of cells and amplification processes. By continually enriching their range of microcarriers, Carroucell ensures optimization for different agitation conditions, ranging from helix to fixed-bed and wave-driven bioreactors.

Cell and gene therapies offer groundbreaking hope for treating currently incurable diseases by harnessing primary cells or their by-products. Advancing these therapies to clinical and industrial stages presents the challenge of producing highly sensitive, adherent cells on a large scale, cost-effectively, and without compromising quality. The sensitive adherent cells used in cell therapy differ greatly from the robust, suspension-cultured cells of the past, necessitating significant adaptations. Despite extensive efforts and exorbitant costs to adapt classic bioproduction technologies, cell therapy clinical trial success rates remain at 10 to 20%, with often mediocre cell quality.

Recognizing the need for a fundamental shift, we developed FlexiGrowTM, the pioneering microcarrier specifically designed for static 2D culture. FlexiGrowTM seamlessly integrates into static 2D systems with ready-to-use protocols for rapid and cost-effective scale-up without any R&D. Bringing 100 to 500% yield increase for your culture in static devices, FlexiGrowTM microcarriers now stands as the only solution to meet the immediate challenges of cell therapy, delivering both quantity and quality to meet market needs.